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Research
- 2023/05/09
- Instant fresh histopathology
- Instant fresh histopathology, the extraordinary technology which combines the H&E rapid staining protocol and the ultimate-high-imaging-speed mesoscale nonlinear optical gigascope to do pathological assessment on excised fresh tissue. Acquiring real-time large-area-stitching H&E images with sub-micron resolution, our technology can preserve the true surgical margin and histological details without causing any artifact. Remarkably, with the speed that at least 4 times faster than frozen-biopsy, Instant fresh histopathology secures an excellent accuracy of 100%, that is indeed comparable to the ultimate solution of formalin-fixed paraffin-embedded (FFPE) biopsy in the clinical trial for brain tumor assessment.
- 2021/11/04
- Clinical Imaging
- UltraFast Optics (UFO) laboratory, led by Prof. Chi-Kuang Sun, has been working on development of the Harmonic Generation Microscopy System (HGM) since the early 2000s, including the Second and Third Harmonic Generation, and more recently the Spectral Third Harmonic Generation (sTHG) Microscopy and the Third Harmonic Generation Enhancement Ratio (erTHG) Microscopy systems. The goal is to device a novel cutting-edge optic system capable of conducting live in vivo imaging deep inside the human body with a super-resolution without fluorophores. In 2003, UFO demonstrated that the HGM system has the capacity to noninvasively view the embryonic morphological changes and complex developmental processes at the cellular and subcellular levels in live zebrafish with a penetration more than 1.5 mm, a resolution less than 500 nm, and for continuously 3 days without any damage or delay on the development. Furthermore, our team was the first to propose using the HGM system to conduct virtual skin biopsy in human, and subsequently demonstrated in multiple clinical trials that the HHGM system is proficient to perform in vivo virtual skin biopsy. This allowed for identification of different skin diseases based on traditional histopathological characters as well as some new information such as melanin distribution, melanocyte dendricity, and the collagen fiber texture. On top of that, the HGM system could also provide data for differential diagnosis involving nonmelanoma pigmented skin lesions. Examination of the molecular structure in people of different age groups also revealed age-associated molecular changes in the skin tissues; including cellular and nuclear size of the basal keratinocytes, depth of the dermal papilla zone, height of isolated dermal papilla and the three-dimensional interdigitation index.
- 2021/11/03
- Extreme Phononics
- Over the years, Prof Sun's laboratory has successfully devised a mechanism to generate sub-terahertz (THz) acoustic waves by combining femtosecond mode-locked laser (pulsewidth < 200 fs) and semiconductor quantum well structures as optical piezoelectric transducers (Lin et al., 2005; Sun, Liang, & Yu, 2000). This technique has allowed Sun and his team to delineate the physical properties of substances that is not only previously unknown, but also unapproachable using conventional methods.